Search results for " Acetonitrile"

showing 10 items of 628 documents

Adsorption and photocatalytic degradation of acetonitrile: FT-IR investigation

2003

Abstract The photocatalytic degradation of acetonitrile was carried out in liquid–solid regime in a batch reactor by using two types of commercial TiO 2 powders (Merck and Degussa P25) as photocatalysts. The concentration of acetonitrile and non-purgeable organic carbon (NPOC) were monitored. The initial rate of acetonitrile conversion was found higher on TiO 2 Merck than on TiO 2 P25. FT-IR spectroscopy was used to investigate the molecular features of the adsorption and photo-oxidation of acetonitrile on the two TiO 2 powders in a fully surface hydrated form. Acetonitrile was found adsorbed on Ti 4+ surface ions and hydroxyl groups for both types of TiO 2 . This interaction appeared fully…

NitrileFF-IR investigationProcess Chemistry and TechnologyInorganic chemistryInfrared spectroscopyCatalysisTiO2; acetonitrile; adsorption; photocatalysis; FF-IR investigationTitanium oxideCatalysisacetonitrilechemistry.chemical_compoundAdsorptionchemistryadsorptionPhotocatalysisTiO2Physical and Theoretical ChemistryFourier transform infrared spectroscopyAcetonitrilephotocatalysis
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The deubiquitinase USP11 is a versatile and conserved regulator of autophagy

2021

Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is important for the precise control of autophagy pathways. Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autophagy and that KO of USP11 in mammalian cells results in elevated autophagic flux. We also demonstrate that depletion of the USP11 homolog H34C03.2 in Caenorhabditis elegans triggers hyperactivation of autophagy and protects the animals against human amyloid-β peptide 42 aggregation-induced paralysis. USP11…

autophagyhAβ42 human amyloid-β protein 1 to 42Lipid kinase activityPI(3)P phosphatidylinositol-3-phosphatemTORC1BiochemistryCell LineGene Knockout Techniqueschemistry.chemical_compoundubiquitinAnimalsHumansULK1 unc-51-like autophagy activating kinase 1WIPI WD-repeat domain phosphoinositide-interacting proteinPI3KC3-C1Caenorhabditis elegansCaenorhabditis elegans ProteinsmTORC1Molecular BiologyMechanistic target of rapamycinUSP11 ubiquitin-specific protease 11proteostasisAmyloid beta-PeptidesS6K S6 kinasebiologyPhosphatidylinositol 3-phosphateAutophagyDUB deubiquitinaseLFQ label-free quantificationIP immunoprecipitationNHT nonhuman targetingPI3KC3-C1 class III phosphatidylinositol 3-kinase complex ICell BiologyACN acetonitrileAβ amyloid-βNRBF2 nuclear receptor-binding factor 2Peptide FragmentsCell biologydeubiquitinase (DUB)ProteostasischemistryProteotoxicitymTORC1 mechanistic target of rapamycin complex 1biology.proteinAutophagy-Related Protein-1 HomologBSA bovine serum albuminThiolester HydrolasesResearch ArticleJournal of Biological Chemistry
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In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

2019

Graphical abstract

In situPO Propylene oxideIV IntravenousP338 Poloxamer 338lcsh:RS1-441Pharmaceutical Sciencechemistry.chemical_compoundn Sample sizeSD Standard deviationIM Intramuscularchemistry.chemical_classificationC0 Analyte plasma concentration at time zeroDoE Design of experimentsUV UltravioletPharmacology. TherapyK2.EDTA Potassium ethylenediaminetetraacetic acidLC–MS/MS Liquid chromatography-tandem mass spectrometryH&E Hematoxylin and eosintmax Sampling time to reach the maximum observed analyte plasma concentrationIn situ forming gelsCMC Critical micellar concentrationCmax Maximum observed analyte plasma concentrationIntramuscular injectionDN Dose normalizedGPT Gel point temperaturePLGA Poly-(DL-lactic-co-glycolic acid)TFA Trifluoroacetic acidCAN AcetonitrileATP Adenosine 5′ triphosphateSalt (chemistry)Polyethylene glycolPoloxamerArticlelcsh:Pharmacy and materia medicaPharmacokineticsIn vivoUHPLC Ultra-high performance liquid chromatographyPharmacokineticsAUClast Area under the analyte concentration versus time curve from time zero to the time of the last measurable (non-below quantification level) concentrationEO Ethylene oxideNMP N-methyl-2-pyrrolidoneComputingMethodologies_COMPUTERGRAPHICSAUC∞ Area under the analyte concentration vs time curve from time zero to infinite timeP407 Poloxamer 407In vitro releasePoloxamerCMT Critical micellar temperatureGel erosionIn vitrot1/2 Apparent terminal elimination half-lifechemistryMDR-TB Multi-drug resistant tuberculosisAUC80h Area under the analyte concentration versus time curve from time zero to 80 htlast Sampling time until the last measurable (non-below quantification level) analyte plasma concentrationMRM Multiple reaction monitoringNuclear chemistrySustained releaseInternational Journal of Pharmaceutics: X
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CCDC 761910: Experimental Crystal Structure Determination

2012

Related Article: H.Arora, S.K.Barman, F.Lloret, R.Mukherjee|2012|Inorg.Chem.|51|5539|doi:10.1021/ic201971t

Space GroupCrystallographybis(mu2-Acetato)-(mu2-4-methyl-2-((3-(pyridin-2-yl)-1H-pyrazol-1-yl)methyl)-6-((3-(pyridin-2-yl)-1H-pyrazol-1-yl)methyl)phenolato)-bis(acetonitrile)-di-zinc(ii) tetraphenylborate acetonitrile solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 817807: Experimental Crystal Structure Determination

2011

Related Article: M.Sarwar, A.M.Madalan, F.Lloret, M.Julve, M.Andruh|2011|Polyhedron|30|2414|doi:10.1016/j.poly.2011.06.011

Space GroupCrystallographyCrystal System(mu~2~-oxo)-bis(mu~2~-22'-(propane-13-diylbis(nitrilomethylylidene))-bis(6-methoxyphenolato))-hexakis(nitrato)-di-gadolinium-di-iron(iii) acetonitrile solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 995946: Experimental Crystal Structure Determination

2015

Related Article: Maria-Gabriela Alexandru, Diana Visinescu, Marius Andruh, Nadia Marino, Donatella Armentano, Joan Cano, Francesc Lloret, Miguel Julve|2015|Chem.-Eur.J.|21|5429|doi:10.1002/chem.201406088

Space GroupCrystallography(mu-22'-(propane-13-diylbis(nitrilomethylylidene))bis(6-methoxyphenolato))-nitrato-tetra-aqua-copper-lanthanum (110-phenanthroline)-tetracyano-iron nitrate acetonitrile solvate monohydrateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 911579: Experimental Crystal Structure Determination

2013

Related Article: M.M.Hanninen,J.Valivaara,A.J.Mota,E.Colacio,F.Lloret, R.Sillanpaa|2013|Inorg.Chem.|52|2228|doi:10.1021/ic302731z

Space GroupCrystallographyCrystal System(mu~3~-Ethane-12-diolato)-bis(mu~2~-4-allyl-2-(((5-allyl-2-oxido-3-methoxybenzyl)(2-(morpholin-4-yl)ethyl)amino)methyl)-6-methoxyphenolato)-(mu~2~-chloro)-chloro-manganese(ii)-di-manganese(iii) acetonitrile solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1983680: Experimental Crystal Structure Determination

2020

Related Article: Erick Ramírez, Md. Kamal Hossain, Marcos Flores-Alamo, Matti Haukka, Ebbe Nordlander, Ivan Castillo|2020|Eur.J.Inorg.Chem.|2020|2798|doi:10.1002/ejic.202000488

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(acetonitrile)-{NN-bis[(1-methyl-1H-benzimidazol-2-yl)methyl]-11-bis(pyridin-2-yl)methanamine}-copper bis(trifluoromethanesulfonate) acetonitrile solvateExperimental 3D Coordinates
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CCDC 1555247: Experimental Crystal Structure Determination

2017

Related Article: Riia Annala, Aku Suhonen, Heikki Laakkonen, Perttu Permi, Maija Nissinen|2017|Chem.-Eur.J.|23|16671|doi:10.1002/chem.201703985

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN6N6'-(12-phenylene)bis(N2-{2-[(benzenecarbonyl)amino]phenyl}pyridine-26-dicarboxamide) acetonitrile solvate monohydrateExperimental 3D Coordinates
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CCDC 1029762: Experimental Crystal Structure Determination

2015

Related Article: José Martínez-Lillo, Joan Cano, Wolfgang Wernsdorfer, Euan K. Brechin|2015|Chem.-Eur.J.|21|8790|doi:10.1002/chem.201500439

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametershexakis(mu-2-(N'-oxidocarbamimidoyl)phenolato)-bis(mu-oxido)-diaqua-hexakis(pyridine)-hexa-manganese hexachloro-rhenium benzene acetonitrile solvate tetrahydrateExperimental 3D Coordinates
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